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Mycobacterium tuberculosis diversity

Mycobacterium tuberculosis Diversity Database

Different M. tuberculosis (TB) strains have varying virulence, immunogenicity, and drug resistance. However, currently sequenced TB genomes are thought to be responsible for only a minority of global TB burden. This whole-genome sequencing project proposes to exploit recently revealed TB global population structure to target 31 rationally selected TB strains, to be sequenced as the representatives of the TB global diversity.

Project Information

Sequencing the genomes of many TB strains is an important step towards understanding the molecular basis of the differences in virulence, immunogenicity, and drug resistance. Multiple TB genome sequences have become available; however, these sequences represent only two of the six main lineages of TB, which are thought to be responsible for only a minority of global TB burden. Therefore, much of the genome sequence diversity of potentially important TB strains remains to be characterized.

This sequencing project was supported by the National Institute of Allergy and Infectious Disease, National Institutes of Health funded Genome Sequencing Center for Infectious Diseases at the Broad Institute.

Data can be found at NCBI:

M. tuberculosis 02_1987

M. tuberculosis EAS054

M. tuberculosis GM 1503

M. tuberculosis T17

M. tuberculosis T85

M. tuberculosis T92

M. tuberculosis 94_M4241A

M. tuberculosis F11

M. tuberculosis H37Rv (GB:AL123456)

M. tuberculosis T46

M. tuberculosis CPHL_A

M. africanum K85

Citing these data

Please cite as: “Mycobacterium tuberculosis Diversity Sequencing Project, Broad Institute of Harvard and MIT (http://www.broadinstitute.org/)”